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Buy SGT-78 Powder
What is SGT-78?
CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. It is a potent agonist for cannabinoid receptors CB1 and CB2. With in vitro EC50 values of 0.58 nM and 6.12 nM, respectively. In mice, CUMYL-4CN-BINACA produces hypothermic and pro-convulsant effects via the CB1 receptor. And anecdotal reports suggest it has an active dose of around 0.1 mg in humans. SGT-78 Powder for sale
CUMYL-4CN-BINACA is metabolize to produce cyanide, raising concerns about liver toxicity. There is one reportcase of hyperthermia, rhabdomyolysis, and kidney failure associated with its use. SGT-78 Powder for sale
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ALPRAZOLAM CHEMICALS. Synthetic cannabinoid receptor agonists (SCRAs) are the largest class of new psychoactive substances (NPS). New examples are detect constantly, and some are associat with a series of adverse effects, including seizures. CUMYL-4CN-BINACA (1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide) is structurally related to potent. Cumylamine-derived SCRAs such as 5F-CUMYL-PINACA, but is unusual due to a terminal aliphatic nitrile group not frequently encountered in SCRAs or pharmaceuticals. We report here that CUMYL-4CN-BINACA is a potent CB1 receptor agonist (K i = 2.6 nM; EC50 = 0.58 nM).order sgt-78 powder | sgt-78| buy sgt-78| research chemicals for sale| buy bendiazepines powders online| research chemical benzodiazepine| research chemicals online| chemical raw material suppliers | research chem supply| raw chemicals suppliers| us chemical supply| chem supply| chemical suppliers online usa| chemical materials suppliers| chem supply store| raw chemical suppliers near me| chemical raw materials distributor| research chemicals supplier| research chemical powder
That produces pro-convulsant effects in mice at a lower dose than reported for any SCRA to date (0.3 mg/kg, i.p). Hypothermic and pro-convulsant effects in mice could be reduced or blocked, respectively, by pretreatment with CB1 receptor antagonist SR141716, pointing to at least partial involvement of CB1 receptors in vivo. Pretreatment with CB2 receptor antagonist AM-630 had no effect on pro-convulsant activity. The pro-convulsant properties and potency of CUMYL-4CN-BINACA may underpin the toxicity associated with this compound in humans.
CUMYL-4CN-BINACA (1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide) (1), also known as 4CN-CUMYL-BUTINACA, CUMYL-CYBINACA, and SGT-78, has been available as a synthetic cannabinoid receptor agonist (SCRA). And new psychoactive substance (NPS) in the European Union and elsewhere since late 2015. With more than 2,400 seizures reported by nine countries (European Monitoring Centre for Drugs and Drug Addiction, 2017; Arıkan Ölmez et al., 2018).
CUMYL-4CN-BINACA has been detect in multiple forms, including liquids and powders. With a single seizure of 50 kg of powder intercepted by Spanish customs en route from China (European Monitoring Centre for Drugs and Drug Addiction, 2017).
Eleven fatalities with analytical confirmation of CUMYL-4CN-BINACA have occurred in the EU, with CUMYL-4CN-BINACA attributed as cause or contributor to death in at least five of these (EMCDDA, 2017). In Turkey, CUMYL-4CN-BINACA was detect in 85 post-mortem blood samples collect from autopsies conduct in the latter half of 2016 (Yeter, 2017). Where to buy SGT-78 Powderhttps://www.alprazolamchemicals.com/product/sgt-78-powder-for-sale/
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